… signal synthesized by mixing ac waves of various frequencies, followed by fast Fourier …
was used as an excitation source, followed by Fourier transform of both excitation and response …

… This study was sponsored by Pharmacyclics. Clinical investigators were responsible for
design of the study protocol and analysis plan together with Pharmacyclics. The investigators …

… for treatment; adequate renal and hepatic function, defined by a creatinine level of no more
than 1.5 … levels were performed during the screening period by a central reference laboratory. …

… by the biometrics group at Janssen Research and Development and were independently
confirmed and validated by a … Manuscript drafts were prepared by all the authors, with editorial …

… Functional analysis showed that the C481S mutation of BTK results in a protein that is
only reversibly inhibited by ibrutinib. The R665W and L845F mutations in PLCγ2 are both …

… might mitigate the effect of ibrutinib by providing an alternate means by which to activate
NF-… mutations more often than would be expected by chance in ABC tumors 5 , suggesting …

… Best clinical response (CR, PR, SD, PD) was determined by investigators based on criteria
defined by the International Working Group revised response criteria for malignant lymphoma…

… and sustained reduction of lymphadenopathy accompanied by transient lymphocytosis, which
is … Our data indicate that inhibition of BTK by PCI-32765 overcomes BCR- and chemokine-…

… cells and T lymphocytes forms an indispensable component of adaptive immunity, yet certain
neoplastic, autoimmune, parasitic, and infectious diseases subvert adaptive immunity by …

… In this study, we instead estimate the higher moments of market returns by extracting
moments implied by daily index option prices. We use the model-free methodology proposed …