Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty …

The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a
key regulator of the production of both neuroprotective (eg kynurenic and picolinic acid, and …

Agricultural intensification can involve the simplification of agroecosystems to crop monocultures
while the practices of crop rotation, intercropping and companion planting maintain …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

We conducted a genome-wide association study (GWAS) of breast cancer by genotyping
528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast …

Aims. This paper describes the Heterodyne Instrument for the Far-Infrared (HIFI) that was
launched onboard ESA's Herschel Space Observatory in May 2009. Methods. The instrument …

The glycoprotein hormone erythropoietin regulates the level of oxygen in the blood by modulating
the number of circulating erythrocytes, and is produced in the kidney 1–4 or liver 5,6 of …

Recently, common variants on human chromosome 8q24 were found to be associated with
prostate cancer risk. While conducting a genome-wide association study in the Cancer …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To understand
how neurotrophins elicit such diverse responses, we elucidated signaling pathways by …

The primary circulating form of vitamin D, 25-hydroxy-vitamin D [25(OH)D], is associated with
multiple medical outcomes, including rickets, osteoporosis, multiple sclerosis and cancer. …