User profiles for M. Curran

Mark Curran

- Verified email at its.jnj.com - Cited by 17235

Michael A Curran

- Verified email at mdanderson.org - Cited by 10457

A review of assessments conducted on bio-ethanol as a transportation fuel from a net energy, greenhouse gas, and environmental life cycle perspective

H Von Blottnitz, MA Curran - Journal of cleaner production, 2007 - Elsevier
Interest in producing ethanol from biomass in an attempt to make transportation ecologically
sustainable continues to grow. In recent years, a large number of assessments have been …

Hypoxic stress: obstacles and opportunities for innovative immunotherapy of cancer

S Chouaib, MZ Noman, K Kosmatopoulos, MA Curran - Oncogene, 2017 - nature.com
Tumors use several strategies to evade the host immune response, including creation of an
immune-suppressive and hostile tumor environment. Tissue hypoxia due to inadequate …

[HTML][HTML] The impact of pre-existing comorbidities and therapeutic interventions on COVID-19

LA Callender, M Curran, SM Bates… - Frontiers in …, 2020 - frontiersin.org
Evidence from the global outbreak of SARS-CoV-2 has clearly demonstrated that individuals
with pre-existing comorbidities are at a much greater risk of dying from COVID-19. This is of …

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

ME Curran, I Splawski, KW Timothy, GM Vincen… - Cell, 1995 - Elsevier
… Both mutations affect amino acids conserved in the eag family of potassiu m channels and
… Plasmid DNA samples were purified and sequenced as previously described (Curran et ai., …

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

MC Sanguinetti, C Jiang, ME Curran, MT Keating - Cell, 1995 - Elsevier
Mutations in HERG cause an inherited cardiac arrhythmia, long OT syndrome (LOT). To
define the function of HERG, we expressed the protein in Xenopus oocytes. The biophysical …

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

Q Wang, ME Curran, I Splawski, TC Burn… - Nature …, 1996 - nature.com
Curran, ME et al. A molecular basis for cardiac antiythmia: HERG mutations cause long
QT syndrome. Cell 80, 795-803. … Shea, and M. Schaffer for their help with LQT kindreds; …

Coassembly of KVLQT1 and minK (IsK) proteins to form cardiac IKS potassium channel

MC Sanguinetti, ME Curran, A Zou, J Shen, PS Specter… - Nature, 1996 - nature.com
THE slowly activating delayed-rectifier K + current, I KS , modulates the repolarization of
cardiac action potentials. The molecular structure of the I KS channel is not known, but …

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

MA Curran, W Montalvo, H Yagita… - Proceedings of the …, 2010 - National Acad Sciences
Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand
(Fvax) combined with antibody blockade of the negative T-cell costimulatory receptor …

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

…, YH Loh, K Thomas, IH Park, M Garber, M Curran… - Nature …, 2010 - nature.com
The conversion of lineage-committed cells to induced pluripotent stem cells (iPSCs) by
reprogramming is accompanied by a global remodeling of the epigenome 1 , 2 , 3 , 4 , 5 , …

PD-L1 expression in triple-negative breast cancer

…, A Akcakanat, A Chawla, M Curran… - Cancer immunology …, 2014 - AACR
Early-phase trials targeting the T-cell inhibitory molecule programmed cell death ligand 1 (PD-L1)
have shown clinical efficacy in cancer. This study was undertaken to determine …