… The degree of familial aggregation can be determined by estimating the ratio of the prevalence
in siblings versus the population prevalence of the disease (λ s ). For MS, the λ s ranges …

… A new T2 or gadolinium-enhancing lesion(s) on follow-up MRI, irrespective of its timing with
… A new T2 or gadolinium-enhancing lesion(s) on follow-up MRI, irrespective of its timing with …

… a non-0602 allele) and DRB1 * 1503-positive chromosomes in African-American individuals
with MS suggest an older African origin for the HLA-associated MS susceptibility gene(s), …

Background There is increasing evidence that B lymphocytes are involved in the pathogenesis
of multiple sclerosis, and they may be a therapeutic target. Rituximab, a monoclonal …

… Today’s talk will cover … • Mononuclear cells >50 per ul or PMN in CSF (>50 cells per μl) or
PMN’s in … , decreased or absent DTR’s, monophasic course with onset-nadir 12h to 28 days …

Background An evolving understanding of the immunopathogenesis of multiple sclerosis
suggests that depleting B cells could be useful for treatment. We studied ocrelizumab, a …

Background B cells influence the pathogenesis of multiple sclerosis. Ocrelizumab is a humanized
monoclonal antibody that selectively depletes CD20+ B cells. Methods In two identical …

Vascular permeability factor (VPF) is a 40-kilodalton disulfide-linked dimeric glycoprotein that
is active in increasing blood vessel permeability, endothelial cell growth, and angiogenesis…

Background The combination of chemotherapy with thoracic radiotherapy (TRT) compared
with TRT alone has been shown to confer a survival advantage for good performance status …

We have examined the role of cyclooxygenase 2 (COX-2) in a model of inflammation in vivo.
Carrageenan administration to the subcutaneous rat air pouch induces a rapid …