Health systems resilience is key to learning lessons from country responses to crises such as
coronavirus disease 2019 (COVID-19). In this perspective, we review COVID-19 responses …

The dissemination of tumour cells is the prerequisite of metastases and is correlated with a
loss of epithelial differentiation and the acquisition of a migratory phenotype, a hallmark of …

Besides climate change impacts on water availability and hydrological risks, the
consequences on water quality is just beginning to be studied. This review aims at proposing a …

In a large collaborative screening project, 370 men with idiopathic azoospermia or severe
oligozoospermia were analysed for deletions of 76 DNA loci in Yq11. In 12 individuals, we …

The innate immune system senses viral infection by recognizing a variety of viral
components (including double-stranded (ds)RNA) and triggers antiviral responses 1 , 2 . The …

The structural basis for the distinction of viral RNA from abundant self RNA in the cytoplasm
of virally infected cells is largely unknown. We demonstrated that the 5′-triphosphate end of …

Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …

We report here that individuals with Noonan syndrome and juvenile myelomonocytic
leukemia (JMML) have germline mutations in PTPN11 and that somatic mutations in PTPN11 …

The extent to which a community outbreak of infection like COVID-19 stresses other parts of
healthcare system like STEMI care is largely unknown. Contemporary COVID-19 infection …

Stratification of women according to their risk of breast cancer based on polygenic risk scores
(PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, …