A third of the world's population uses solid fuel derived from plant material (biomass) or coal
for cooking, heating, or lighting. These fuels are smoky, often used in an open fire or simple …

… Lam 4 further recognized that because each bead encountered only one amino acid at each
coupling … Its structure was determined from MS experiments and the activity (K i = 4 μM) was …

Cardiac involvement by primary and secondary tumors is one of the least investigated
subjects in oncology. Seven cases of primary and 154 cases of secondary cardiac tumors from …

We adopted a rational approach to design cationic lipids for use in formulations to deliver
small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-…

Epidemiological studies have implicated obstructive sleep apnea (OSA) as an independent
comorbid factor in cardiovascular and cerebrovascular diseases. It is postulated that …

OUR aim was to improve techniques for drug development by facilitating the identification of
small molecules that bind with high affinity to acceptor molecules (for example, cell-surface …

Detection of hypertension and blood pressure control are critically important for reducing
the risk of heart attacks and strokes. We analyzed the trends in the prevalence, awareness, …

We have generated mice that carry a germline mutation in which a large portion of the RAG-2
coding region is deleted. Homozygous mutants are viable but fail to produce mature B or T …

The opportunity to harness the RNA interference (RNAi) pathway to silence disease-causing
genes holds great promise for the development of therapeutics directed against targets that …

Gene targeting experiments have demonstrated that the expression of immunoglobulin heavy
chain in the pre-B cell receptor (pBCR) and of heavy and light chains in the B cell antigen …